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KMID : 0604520110370030257
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Journal of the Society of Cosmetic Scientists of Korea
2011 Volume.37 No. 3 p.257 ~ p.264
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Study on the Antioxidative Activities and Anti-Inflammatory Effect of Kaempferol and Kaempferol Rhamnosides
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Lee Keun-Ha
Cho Young-Long
Joo Chul-Gue
Joo Yeon-Jeong
Kwon Sun-Sang
Ahn Soo-Mi
Oh Su-Jin
Roh Ho-Sik
Park Chung
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Abstract
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In this study, to evaluate the antioxidative activities and anti-inflammatory effects of kaempferol and its rhamnosides, we performed the free radical scavenging assay, ROS inhibition assay and TARC (thymus and activation-regulated chemokine) assay. Also, we studied physiological activity of kaempferol and its rhamnosides (α-rhamnoisorobin, afzelin, kaempferitn) by structure-activity relations. The free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activities were determined with kaempferol (62.5 μM) and α-rhamnoisorobin (50.0 μM) but afzelin and kaempferitrin did not show free radical scavenging activities. Kaempferol showed a 97.5, 57.8, 47.8 % inhibition of ROS (reactive oxygen species) generated at concentrations of 10, 50 and 100 μM, compared to control (100 %). α-rhamnoisorobin showed a 93.1, 59.1 and 41.4 % inhibition of ROS at the same concentration. We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC expression. Kaempferol showed a 48.8, 5.5 and 4.4 % inhibition of TARC generated at 10, 50 and 100 μM, compared to control. α-Rhamnoisorobin showed a 88.1, 19.0 and 1.0 % inhibition of TARC generated at the same concentration. In conclusion, these results indicate that kaempferol and α-rhamnoisorobin have good antioxidative activities and anti-inflammatory effects that could be applicable to new functional cosmetics for anti-aging and anti-inflammation.
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KEYWORD
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kaempferol, kaempferol rhamnosides, antioxidative activity, anti-inflammatory effect, 1) functional cosmetics
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